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Abstract
Breadfruit starch can be used as a binder on the chewable tablet because it consists of amylose and amylopectin which can increase the cohesiveness and make a good bond with the powder. Guava leaves extract can kill the bacterial growth of Streptococcus mutans so it can be served to prevent dental caries. This research aimed to know whether increased concentrations of breadfruit starch can affect the physical characteristics of the chewable tablet of guava leaves extract. The chewable tablets were formulated into 4 formulas with different concentration of mucilago breadfruit starch, such as 10%, 13%, 16% and 19%. Breadfruit starch as a binder obtained from an almost ripe the breadfruit and then was crushed and soaked to occur separation between water immersion and amylum, and then amylum was dried and made as mucilago and the mucilago was added into the formula. The result of the characteristic of starch, the powder was true breadfruit starch. The flowability and particle size distribution of granule was evaluated. Then, the granule was made into the chewable tablet. The research result showed that the increase of mucilago breadfruit starch concentration increased the hardness and decreased friability of chewable tablet.
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References
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Nursal KF, Indriani O, Dewantini LA. 2014. Penggunaan Na-Cmc Sebagai Gelling Agent Dalam Formula Pasta Gigi Ekstrak Etanol 70% Daun Jambu Biji (Psidium Guajava L). Jurnal Farmasains Uhamka. 1(1).
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Siregar CJP. 2010. Teknologi Farmasi Sediaan Tablet. Jakarta (ID): Penerbit Buku Kedokteran EGC.
Tampedje AAD, Tuda JSB, Michael AL. 2016. Uji Efek Antibakteri Ekstrak Daun Jambu Biji (Psidium Guajava Linn.) Terhadap Pertumbuhan Koloni Streptococcus Mutan. Pharmacon. Jurnal Ilmiah Farmasi – Unsrat. 5(3): 222-228.
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References
Departemen Kesehatan RI. 1979. Farmakope Indonesia Edisi III. Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan.
Departemen Kesehatan RI. 2008. Farmakope Herbal Indonesia Edisi 1. Jakarta (ID): Direktorat Jenderal Pengawasan Obat dan Makanan.
Departemen Kesehatan RI. 2014. Farmakope Indonesia Edisi V. Jakarta (ID): Direktorat Jenderal Pengawasan Obat dan Makanan.
Enauyatifard R, Azadbakht M, Fadakar Y. 2012. Assisment of ferula gummosa gum as abinding agent in tablet formulations. ActaPoloniacpharma. Drug Research. 69(2):291-8
Guntara M. 2012. Pengaruh Pati Sukun (Artocarpus altilis (Park.) Fosberg.) Terpregelatinasi Fosfat Sebagai Matriks Terhadap Disolusi Tablet Lepas Lambat Teofilin [skripsi]. Jakarta (ID): Fakultas Farmasi dan Sains UHAMKA.
Ifmaily. 2018. Penetapan Kadar Pati Buah Sukun (Artocarpus altilis L) dengan Metode Luff Schoorl. Chempublish Journal. 3(1): 1-10. https://doi.org/10.22437/chp.v3i1.5056
Lachman L, Lieberman HA, Kanig JL. 1994. Pharmaceutical Dosage Form Volume 1. New York (US): Macell Dekker Inc.
Mendez RC, Anaebonam AO. 1990. Chewable Tablets. In: Encyclopedia of Pharmaceutical Technology Vol. 2. New York and Basel (US): Marcel Dekker Inc.
Nursal KF, Indriani O, Dewantini LA. 2014. Penggunaan Na-Cmc Sebagai Gelling Agent Dalam Formula Pasta Gigi Ekstrak Etanol 70% Daun Jambu Biji (Psidium Guajava L). Jurnal Farmasains Uhamka. 1(1).
Prabu GR, Gnanamani A, Sadulla S. 2006. Guaijaverin: a plant flavonoid as potential antiplaque agent against Streptococcus mutans. Journal compilation The Society for Applied Microbiology, Journal of Applied Microbiology. 101(2):487-95.
Siregar CJP. 2010. Teknologi Farmasi Sediaan Tablet. Jakarta (ID): Penerbit Buku Kedokteran EGC.
Tampedje AAD, Tuda JSB, Michael AL. 2016. Uji Efek Antibakteri Ekstrak Daun Jambu Biji (Psidium Guajava Linn.) Terhadap Pertumbuhan Koloni Streptococcus Mutan. Pharmacon. Jurnal Ilmiah Farmasi – Unsrat. 5(3): 222-228.
Winarno FG. 2004. Kimia Pangan Dan Gizi. Jakarta (ID): PT. Gramedia Pustaka Utama.