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Submitted
June 14, 2019
Published
March 29, 2019
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Abstract
Penelitian ini bertujuan untuk membuktikan khasiat JAMSI, Jamu antidiabetes PT. Mahkotadewa Indonesia, secara preklinis pada tikus diabetes yang diinduksi dengan streptozotocin. Tikus jantan Sprague Dawley sebanyak 36 ekor dibagi secara acak menjadi 6 kelompok (masing-masing kelompok 6 tikus): kelompok normal, kelompok kontrol diabetes (diinduksi + air saline), kelompok kontrol positif (diinduksi + Glibenclamide 2.5 mg/kg BB), dan tiga kelompok perlakuan (diinduksi + JAMSI dengan dosis 0.27, 0.81, dan 1.62 ml/kg BB). Perlakuan diberikan selama 28 hari setelah diinduksi dengan streptozotocin. Pemberian JAMSI 1.62 ml/kg BB terbukti mempengaruhi penurunan kadar glukosa darah dan hemoglobin terglikosilasi (HbA1C) dibandingkan kelompok diabetes. Hasil ini mengindikasikan bahwa JAMSI berkhasiat sebagai antidiabetes.
Keywords
Antidiabetes
Glukosa darah
HbA1C
JAMSI
Article Details
How to Cite
Harmanto, N., Maulidya, I., & Nurcholis, W. (2019). Khasiat Jamu Antidiabetes pada Tikus Sprague Dawley yang Diinduksi Streptozocin. Jurnal Jamu Indonesia, 4(1), 37–41. https://doi.org/10.29244/jji.v4i1.94
References
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Ahmad AN, Mat Daud Z ‘Azuan, Ismail A. 2016. Review on potential therapeutic effect of Morinda citrifolia L. Current Opinion in Food Science. 8:62–67
Augustine AW, Narasimhan A, Vishwanathan M, Karundevi B. 2014. Evaluation of antidiabetic property of Andrographis paniculata powder in high fat and sucrose-induced type-2 diabetic adult male rat. Asian Pacific Journal of Tropical Disease. 4:S140–47
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Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice. 103(2):137–49
Jeffcoate SL. 2004. Diabetes control and complications: the role of glycated haemoglobin, 25 years on. Diabetic Medicine. 21(7):657–65
Koye DN, Magliano DJ, Reid CM, Pavkov ME, Chadban SJ, et al. 2019. Trends in Incidence of ESKD in People With Type 1 and Type 2 Diabetes in Australia, 2002-2013. American Journal of Kidney Diseases. 73(3):300–308
Lau DCW. 2010. Diabetes and weight management. Primary Care Diabetes. 4:S24–30
Mora F, Lluch I, Ascaso J, Pascual I, Sempere J, et al. 1998. Esophageal motor disorders in diabetes mellitus patients with slight cardiovascular neuropaty. Gastroenterology. 114:A233
Takeda K, Nakamura K, Yagi T, Tatumi T, Moriguchi J, Ikeda M. 2014. The effect of sitagliptin on blood pressure in hypertension with diabetes melitus. Journal of the American Society of Hypertension. 8(4, Supplement):e110–11
Zhang X, Cui X, Li F, Wang S, Liu X, et al. 2014. Association between diabetes mellitus with metabolic syndrome and diabetic microangiopathy. Experimental and Therapeutic Medicine. 8(6):1867–73.
References
Kemenkes] Kementrian Kesehatan. 2014. Situasi dan Analisis Diabetes. Jakarta (ID)
Ahmad AN, Mat Daud Z ‘Azuan, Ismail A. 2016. Review on potential therapeutic effect of Morinda citrifolia L. Current Opinion in Food Science. 8:62–67
Augustine AW, Narasimhan A, Vishwanathan M, Karundevi B. 2014. Evaluation of antidiabetic property of Andrographis paniculata powder in high fat and sucrose-induced type-2 diabetic adult male rat. Asian Pacific Journal of Tropical Disease. 4:S140–47
Burda N, Mema V, Mahmudi E, Selimi B, Zhugli S, et al. 2013. Prevalence of dry eye syndrome at patients with diabetus melitus TIP 2. Journal of Acute Disease. 2(1):48–51
Easmin S, Sarker MZI, Ghafoor K, Ferdosh S, Jaffri J, et al. 2017. Rapid investigation of α-glucosidase inhibitory activity of Phaleria macrocarpa extracts using FTIR-ATR based fingerprinting. Journal of Food and Drug Analysis. 25(2):306–15
Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice. 103(2):137–49
Jeffcoate SL. 2004. Diabetes control and complications: the role of glycated haemoglobin, 25 years on. Diabetic Medicine. 21(7):657–65
Koye DN, Magliano DJ, Reid CM, Pavkov ME, Chadban SJ, et al. 2019. Trends in Incidence of ESKD in People With Type 1 and Type 2 Diabetes in Australia, 2002-2013. American Journal of Kidney Diseases. 73(3):300–308
Lau DCW. 2010. Diabetes and weight management. Primary Care Diabetes. 4:S24–30
Mora F, Lluch I, Ascaso J, Pascual I, Sempere J, et al. 1998. Esophageal motor disorders in diabetes mellitus patients with slight cardiovascular neuropaty. Gastroenterology. 114:A233
Takeda K, Nakamura K, Yagi T, Tatumi T, Moriguchi J, Ikeda M. 2014. The effect of sitagliptin on blood pressure in hypertension with diabetes melitus. Journal of the American Society of Hypertension. 8(4, Supplement):e110–11
Zhang X, Cui X, Li F, Wang S, Liu X, et al. 2014. Association between diabetes mellitus with metabolic syndrome and diabetic microangiopathy. Experimental and Therapeutic Medicine. 8(6):1867–73.
Ahmad AN, Mat Daud Z ‘Azuan, Ismail A. 2016. Review on potential therapeutic effect of Morinda citrifolia L. Current Opinion in Food Science. 8:62–67
Augustine AW, Narasimhan A, Vishwanathan M, Karundevi B. 2014. Evaluation of antidiabetic property of Andrographis paniculata powder in high fat and sucrose-induced type-2 diabetic adult male rat. Asian Pacific Journal of Tropical Disease. 4:S140–47
Burda N, Mema V, Mahmudi E, Selimi B, Zhugli S, et al. 2013. Prevalence of dry eye syndrome at patients with diabetus melitus TIP 2. Journal of Acute Disease. 2(1):48–51
Easmin S, Sarker MZI, Ghafoor K, Ferdosh S, Jaffri J, et al. 2017. Rapid investigation of α-glucosidase inhibitory activity of Phaleria macrocarpa extracts using FTIR-ATR based fingerprinting. Journal of Food and Drug Analysis. 25(2):306–15
Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice. 103(2):137–49
Jeffcoate SL. 2004. Diabetes control and complications: the role of glycated haemoglobin, 25 years on. Diabetic Medicine. 21(7):657–65
Koye DN, Magliano DJ, Reid CM, Pavkov ME, Chadban SJ, et al. 2019. Trends in Incidence of ESKD in People With Type 1 and Type 2 Diabetes in Australia, 2002-2013. American Journal of Kidney Diseases. 73(3):300–308
Lau DCW. 2010. Diabetes and weight management. Primary Care Diabetes. 4:S24–30
Mora F, Lluch I, Ascaso J, Pascual I, Sempere J, et al. 1998. Esophageal motor disorders in diabetes mellitus patients with slight cardiovascular neuropaty. Gastroenterology. 114:A233
Takeda K, Nakamura K, Yagi T, Tatumi T, Moriguchi J, Ikeda M. 2014. The effect of sitagliptin on blood pressure in hypertension with diabetes melitus. Journal of the American Society of Hypertension. 8(4, Supplement):e110–11
Zhang X, Cui X, Li F, Wang S, Liu X, et al. 2014. Association between diabetes mellitus with metabolic syndrome and diabetic microangiopathy. Experimental and Therapeutic Medicine. 8(6):1867–73.