Jurnal Jamu Indonesia

Jamu as Indonesian Cultural Heritage and Modern Health Innovation

Waras Nurcholis — 2024-02-16

Total Phenolic Content in Black Rice (Oryza sativa L. indica) Bran Ethanolic Extract from Two Different Regions in Java, Indonesia

Afifah Vardhani — 2024-02-16

Rice bran, a rice by-product yielded by the milling process, has recently been recognized as a potential source of natural active constituents. Black rice bran has the highest antioxidant capacity compared to white and brown rice bran. It is correlated with the contribution of phenolic compounds in rice bran. The purpose of this study was to determine the total phenolic content in black rice (Oryza sativa L. indica) bran ethanolic extract from two different regions in Java, Indonesia, using Folin-Ciocalteu Reagent (FCR). Black rice bran samples used in this study were planted in Ciletuh Geopark Sukabumi, West Java (BRBE1), and Karanganyar Regency, Central Java (BRBE2). The parameters observed were total phenolic content, and the result was statistically tested with an unpaired t-test by GraphPad Prism 8.3.0 application. The samples contained 175.48 mg GAE/g extract in BRBE1 and 174.39 mg GAE/g extract in BRBE2. There was no significant difference based on these results. It can be concluded that both samples contained phenolic compounds and statistically, there was no significant difference.

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Jurnal Jamu Indonesia JJI — 2024-02-26

Ethnopharmacy Study of Medicinal Plants Lampung Tribe in Pekon Tabuan Island, District Cukuh Balak, Tanggamus Regency, Lampung Province

Zulpakor Oktoba — 2024-02-20

People in the Indonesian archipelago have long used medicinal plants as an alternative disease treatment. Tabuan Island is an area in Cukuh Balak District, Tanggamus Regency, Lampung Province, where most people are Lampung Peminggir /Pesisir tribe who still practice empirical medicine with local wisdom. Ethnopharmacy studies on Tabuan Island in the Lampung tribe have never been conducted and published. The study aimed to explore the knowledge of local communities regarding the types of medicinal plants for the search and development of new medicines. This research method includes area studies and descriptive studies in the form of ethnopharmacognosy-ethnopharmacology approaches in the Tabuan island community in 4 (four) villages or Pekon namely Pekon Sawang Balang, Pekon Suka Banjar, Pekon Kuta Kakhang, and Pekon Karang Buah used participatory observation methods and open interviews. The results showed that the Lampung Peminggir ethnic group on Tabuan Island still maintains ethnopharmaceutical traditions by utilizing plants used as medicine in 36 families of 76 species to treat diseases used singly or as a concoction accompanied by jampi. The most widely used plant families are Fabaceae, Zingiberaceae, Malvaceae, Meliaceae, and Poaceae. These medicinal plants in the Fabaceae family are most widely used to remedy mouth ulcers and skin problems such as tinea versicolor, ringworm, itching, acne, dandruff, diarrhea, and diabetes. Leaves are the most widely used plant parts, as much as 49.52%, and the least used plant parts are herbs, thallus, and fungi, while most of these plants are obtained in the garden. The most common way of processing medicinal plants is by stewing.

The Potential of Ethanol Extract of Temu Kunci (Boesenbergia rotunda (L.) Mansf.) Rhizomes as an Anticonvulsant Against Male White Rats

Agustin Yumita Pabenjanan — 2024-02-28

The temu kunci extract was previously reported to have quite good antioxidant activity. One of the causes of seizures is oxidative stress. There has yet to be much exploration of temu kunci extract as an anticonvulsant. This study examines the anticonvulsant activity of 70% ethanol extract of Boesenbergia rotunda (L.) Mansf. against male white rats. The parameters observed were the onset and duration of HLE (Hind Limb Extension) with a digital electroconvulsiometer with a power of 150 mAmp and 50 hertz for 0.2 seconds. The test group was divided into five treatment groups, namely group 1 to group 3 (K1-K3), with extract doses: 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW, respectively, while K4 was a positive control using valproic acid (Depakote 1.54 mg/kgBW), and normal control group (K5) with Na-CMC 0.5%. The results were analyzed using one-way ANOVA and continued with the Tukey test. From the research carried out, information was obtained that 70% ethanol extract of temu kunci at a dose of 400 mg/kgBB had the best potential as an anticonvulsant in prolonging the onset of HLE (seconds) and shortening the duration of HLE (seconds) in mice comparable to the positive control. Temu kunci has the potential to be further developed as an anticonvulsant drug candidates in the future.

Anatomy and Histochemistry of Alliaceae and Iridaceae Species: Quality Control of Traditional Medicine Raw Materials

Reny Syahruni — 2024-02-28

Alliaceae (Allium cepa and Allium ascalonicum) and Iridaceae (Eleutherine bulbosa) are widely used as spices, condiments, and traditional medicine. These three species are vulnerable to adulteration because they are morphologically similar in shape and colour. This study aims to identify and authenticate the three samples through anatomical and histochemical approaches. Anatomical and histochemical analyses were performed on fresh sections of the bulbs samples according to standard anatomical procedures with a razor blade and identification of the main compound groups using specific reagents. Anatomically, the three samples had similar patterns and cell organelles (cell nucleus, cytoplasm, and cell wall). Histochemical techniques identified the presence of alkaloids, phenolics, lipophilics, and terpenoids groups. Histochemical techniques can be applied in identifying the compound groups of the three samples and can be used as an alternative in testing the quality control of traditional medicine raw materials.

Potential of Active Compounds in Broadleaf Mahogany (Swietenia macrophylla) Seeds Against Breast Cancer Cells Based on In Silico Study

Hanifah Dwi Cahya — 2024-02-28

Breast cancer is a leading cause of cancer-related deaths in Indonesia. However, the drugs that are commonly used for treatment can cause side effects and become resistant over time. A study was conducted to test the cytotoxic activity of broadleaf mahogany (Swietenia macrophylla) seed extract on MCF-7 breast cancer cells in vitro. The study aimed to predict active compounds in the broadleaf mahogany seeds that have the potential to act as anti-breast cancer agents using in silico analysis. Molecular docking, visualization of the interaction between the receptor and the ligands, and physicochemical analysis were used to determine the most promising compounds. The receptors used were fibroblast growth factor receptor 1 (FGFR1), vascular endothelial growth factor receptor 2 (VEGFR2), insulin-like growth factor type 1 receptor (IGF-1R), estrogen receptor (ER-α), and progesterone receptor (PR). The results showed that 12 compounds have the potential to be active as anti-breast cancer agents. Three of these compounds, 3β,6-dihydroxydihydrocarapine, stigmasterol, and 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one, were predicted to have similar mechanisms of inhibition as a comparator drug based on binding site similarity values. These compounds are predicted to be taken orally and are promising for further research.