Jurnal Jamu Indonesia http://jamu.journal.ipb.ac.id/index.php/JJI <p>Jurnal Jamu Indonesia (JJI) didedikasikan untuk pertukaran informasi dan pemahaman keilmuan yang meluas mengenai pengembangan dunia jamu melalui penerbitan makalah-makalah Ilmiah.&nbsp; Tema makalah ilmiah yang menjadi lingkup JJI meliputi tema riset jamu dari hulu kehilir yang tidak terbatas pada riset etnobotani dan pengetahuan lokal, eksplorasi, konservasi, domestikasi sumberdaya hayati terkait jamu, pemuliaan varietas, pengembangan <em>Good Agricultural and Collection Practices (GACP)</em> bahan baku jamu, pengembangan standar bahan baku dan produk jamu, pengembangan produk jamu, identifikasi senyawa aktif serta sintesisnya, mekanisme kerja bioaktivitas formula jamu, aspek sosial dan ekonomi terkait dengan pengembangan jamu.</p> en-US <p><a href="http://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license"><img style="border-width: 0;" src="https://i.creativecommons.org/l/by-nc-sa/4.0/88x31.png" alt="Creative Commons License"></a><br>This work is licensed under a <a href="http://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a>. <span style="font-weight: 400;">Copyright @2017. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (</span><a href="http://creativecommons.org/licenses/by-nc-sa/4.0/"><span style="font-weight: 400;">http://creativecommons.org/licenses/by-nc-sa/4.0/</span></a><span style="font-weight: 400;">) which permits unrestricted non-commercial used, distribution and reproduction in any medium </span></p> mra@apps.ipb.ac.id (Mohamad Rafi) jurnaljamuindonesia@apps.ipb.ac.id (Titis Arifiana) Mon, 30 May 2022 03:40:27 +0000 OJS 3.3.0.8 http://blogs.law.harvard.edu/tech/rss 60 Editorial http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/267 <p>Puji dan syukur kami panjatkan kepada Tuhan Yang Maha Esa atas rahmat dan hidayahNya, Jurnal Jamu Indonesia Volume 6 No 2 tahun 2021 dapat diterbitkan. Jurnal Jamu Indonesia merupakan media untuk diseminasi hasil penelitian yang berkaitan dengan jamu di Indonesia. Jamu telah dikenal lama penduduk Indonesia sebagai salah satu pengobatan. Berbagai tanaman di Indonesia sangat berpotensi sebagai jamu. Penelitian tanaman obat dari bagian daun, batang, dan rimpang tanaman telah banyak dilakukan dan terus berkembang.<br>Jurnal Jamu Indonesia pada Volume 7 No 1 Tahun 2022 terdiri atas 5 naskah. Naskah diterbitkan memiliki tema beragam, meliputi: uji aktivitas antioksidan dan anti-penuaan dari ekstrak buah dan daun tanaman Zodia (<em>Evodia suaveolens</em>), formulasi granul efervesen dari ekstrak daun torbangun dengan daging buah asam jawa, analisis penambatan molekuler senyawa isoflavonoid dari tanaman dadap ayam sebagai agen trombolitik pada penyakit infark miokard, seleksi dan dugaan senyawa aktif dari beberapa spesies Asteraceae sebagai inhibitor tirosinase, dan ramuan herbal indonesia sebagai peningkat daya tahan tubuh (suatu review).<br><span style="text-decoration: line-through;">&nbsp;<br></span>Redaksi mengucapkan terima kasih kepada seluruh penulis atas partisipasinya dalam berbagi hasil penelitiannya melalui publikasi di Jurnal Jamu Indonesia. Redaksi juga mengucapkan terima kasih kepada seluruh reviewer atas partisipasinya dalam meningkatkan kualitas tulisan naskah jurnal di edisi ini. Semua hasil karya tersebut akan diarsipkan sebagai dokumentasi berharga demi terjaganya informasi yang dapat menjadi sumber pengembangan ilmu pengetahuan di masa depan. Kontribusi publikasi peneliti-peneliti dan pejuang Jamu Indonesia terus kami harapkan untuk dapat disampaikan di dalam Jurnal Jamu Indonesia ini. Peningkatan kontribusi jumlah dan kualitas tulisan yang telah dan akan dimasukkan akan dapat membantu pengembangan jurnal ini, dan pada saatnya diharapkan juga dapat menjadikan Jurnal Jamu Indonesia menjadi referensi baik secara nasional, maupun internasional.<br><br>Mei 2022<br><strong>Waras Nurcholis</strong><br>Wakil Ketua Dewan Redaksi</p> Waras Nurcholis Copyright (c) 2022 Jurnal Jamu Indonesia http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/267 Mon, 30 May 2022 00:00:00 +0000 Twelve Asteraceae Species as Tyrosinase Inhibitors: Selection and Assumption of Active Compounds http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/250 <p style="text-align: justify;"><em><span style="font-family: 'Bahnschrift Light',sans-serif;">Some Asteraceae plants have phytochemicals that are commonly used to treat some illness. However, research on the use of Asteraceae plants as tyrosinase inhibitor agents is still rare. Therefore, this study aims to select the most active fraction of Asteraceae species as tyrosinase inhibitors and suspect active compounds that play a role in it. About 12 species from Asteraceae are extracted using water. The resulting filtrate is partially fractionated using chloroform to obtain water extracts, water fractions, and chloroform fractions. Each extract and fraction of each plant determined the activity of its tyrosinase inhibitor using a microplate reader (ELISA) with L-DOPA as the substrate. Thitonia diversipholia water fraction provided the best activity of all the samples tested with the smallest IC<sub>50.</sub> The active compounds contained are analyzed using LC-MS / MS. Compounds that act as tyrosinase inhibitors are alkaloid group that dominate the plant, namely trigonelline.</span></em></p> Veby Tri Yani, Irma Herawati Suparto, Irmanida Batubara Copyright (c) 2022 Jurnal Jamu Indonesia http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/250 Mon, 30 May 2022 00:00:00 +0000 Molecular Docking Study of Isoflavonoid Erythrina variegata To Plasminogen Receptor as Thrombolytic Agent on Myocardial Infarction Disease http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/172 <p><em>Erythrina variegata is one of the plants that have efficacy as thrombolytic agent. Isoflavonoid compound has the potential to accelerate the changes of plasminogen which plays important role in the forming of fibrin, that causes the formation of fibrin clots that can clog the arteries thus causing myocardial infarction</em><em>. </em><em>This study aim</em><em>ed</em> <em>to look at the activity of isoflavonoid compounds from Erythrina variegata bark which are expected to be candidates for thrombolytic drugs. This research aims at looking for the </em><em>interaction</em><em> of isoflavonoid compounds of bark which is expected can be thrombolytic drug candidates. The method used in this research was the molecular docking with Autodock Vina and PyMOL software. The results showed that the value of ΔG binding affinity as ligands standard streptokinase -8.4 kcal/mol and isoflavonoid derivatives that have ΔG binding affinity value was lowest for the folitenol -11.5 kcal / mol and orientanol C -11.4 kcal/mol. </em><em>C</em><em>an be concluded that isoflavonoid derivatives in Erythrina variegata have better binding potential compared to streptokinase as standard ligands.</em></p> Rizky Arcinthya Rachmania, Hariyanti, Dewi Susilawati Copyright (c) 2022 Jurnal Jamu Indonesia http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/172 Mon, 30 May 2022 00:00:00 +0000 Antioxidant and Anti-aging Activities from Zodia (Evodia suaveolens J.R. Forst & G. Forst) Fruit and Leaf Extract http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/169 <p><em>Aging is a natural process that occurs in every living organism, including humans. Skin wrinkle, caused by deterioration activity of the elastase enzyme, is one example of the aging process.</em><em> The activity of the elastase enzyme could be inhibited by flavonoid and phenolic compounds. Zodia (Evodia suaveolens) from the family of Rutaceae is one of the indigenous Indonesian plants widely known as rich in flavonoid and phenolic compounds</em><em>. The purpose of this study is to explore antioxidant and anti-aging activity from ethanolic extract of fruit and leaf Zodia</em><em>. The extracts were prepared by refluxing fruit and leaf zodia in 96% ethanol. The obtained extracts were characterized for the phytochemical constituent and its antioxidant activity determined using the 2,2-diphenyl-1-picrylhydrazyl method as well as anti-elastase activity for anti-aging evaluation.</em><em> Phytochemical analysis of both samples showed the presence of flavonoids, saponins, tannins, steroids and essential oils. The calculation of IC<sub>50</sub> in antioxidant activity using the DPPH method showed that ethanolic extract of zodia leaf (264.15 ppm) was higher compared to fruit extract (121.59 ppm). The fruit extract was further tested for anti elastase activity with IC<sub>50</sub> of 145.67 ppm. In conclusion, the presence of phytochemicals in zodia fruit may be responsible for the antioxidant and anti-aging activities. </em></p> Greesty F. Swandiny, Yesi Desmiaty, Haura Usna Rahmah Copyright (c) 2022 Jurnal Jamu Indonesia http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/169 Mon, 30 May 2022 00:00:00 +0000 Effervescent Granule Formulation Combination of Coleus amboinicus Leaves Extract and Tamarindus indica Pulp Extract http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/214 <p><em>Coleus amboinicus</em><em> and Tamarindus indica effectively decrease glucose in the blood with work mechanisms by reducing oxidative stress in the body. Flavonoid contains in these plants was thought to play a role as anti-diabetes. This study made an effervescent granule preparation from a mixture of</em> <em>Coleus amboinicus</em> <em>leaf extract and Tamarind (Tamarindus indica) pulp, with additional ingredients of citric acid, tartaric acid, and sodium bicarbonate. The effervescence reaction masked the extract's unpleasant taste. The three effervescent granule formulas manufacture using a dry granulation method. Each formula used a different amount of acid and base. Effervescent granule testing includes organoleptic, flow rate, angle of repose, froth height, froth time, and hedonic test. The granule quality test results show that the best effervescent granule is formula 1, which contains 7% citric acid, 14% tartaric acid, and 25% sodium bicarbonate. Formula 1 had the best high froth 0.5 cm and 2 minute 18 seconds froth time and preferred by the panelists based on aroma and taste. </em></p> Erni Rustiani, Ulfa Nur Awinda Copyright (c) 2022 Jurnal Jamu Indonesia http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/214 Mon, 30 May 2022 00:00:00 +0000 Review: Indonesian Herbal Ingredients as Immune Booster http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/253 <p><em>The COVID-19 pandemic caused by SARS-CoV-2 virus lead to massive death counts in parts of the world, including in Indonesia. Indonesian people often use herbal medicine as a way to increase their immune system, to prevent infection, and to accelerate the healing process of COVID-19. They are used to compose herbs with several medicinal plants as ingredients. This review was aimed to provide information about immune booster herbs in Indonesia along with how to make it, its composition, its chemical contents, and how to use it in order to obtain scientific basis in understanding the efficacy and the herbal formulation. The method was carried out by browsing the literature from 2011-2021 through Google Scholar database from September 2021 to October 2021. The keywords used were "immune booster", “immune boosting herbs”, “jamu”, “herbal ingredient”, “formulation” using the Boolean Operators 'AND' 'OR' and ‘NOT’. The literature that met the inclusion criteria were 30 journals. From the literature review, it was known that there are 22 species of medicinal plants that are used for 37 immune booster jamus with Zingiberaceae as the majority of the family (31%). The top ten plants commonly found in the ingredients are turmeric, ginger, lemongrass, temulawak, cinnamon, red ginger, lime, lesser galangal, meniran, and centella asiatica. Based on the plant’s chemical constituents, it was found that the secondary metabolites components which could potentially boost immunity are essential oils, flavonoids, saponins, tannins, and phenols. Meanwhile, the active compounds for immune booster were curcumin, gingerol, xanthorrhizol, citral, p-methoxycinnamate, and philanthine.</em></p> Yasmiwar Susilawati, Norisca Aliza Putriana, Silmi Auliya Zakariya Copyright (c) 2022 Jurnal Jamu Indonesia http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/253 Mon, 30 May 2022 00:00:00 +0000